Gao Lab

Understanding the RNA Metabolism Mechanisms underlying Cardiovascular Diseases

Publications

  1. He M, Tay WT, Song N, Liu T, Ren SV, Zhu C, Onubogu N, Biler O, Tan JE, Keezer C, He X, Pham A, Sheng S, Ding H, Lin J, Wang L, Wang Y, Hu X, Wang Y, Gao C, “Cardioprotective role of RBFox1 in myocardial infarction-induced heart failure.”, Cardiovascular research, 2025, 2534-2548, Doi:10.1093/cvr/cvaf206 PMID:41294183
  2. Zhu J, Gao C, Wang Y, “Minimally Invasive Aortic Regurgitation Surgery: A Mouse Model of Volume Overload-Induced Cardiac Remodeling by Aortic Regurgitation.”, JACC. Basic to translational science, 2025, 101348, Doi:10.1016/j.jacbts.2025.101348 PMID:40956258
  3. Saleem MZ, Liu T, Song N, McReynolds J, Gao C, “Myocardial damage post short-term self-administration cocaine usage in rat.”, Journal of molecular and cellular cardiology plus, 2025, 100475, Doi:10.1016/j.jmccpl.2025.100475 PMID:40686504
  4. Wang M, Liu Z, Ren S, Zhu J, Morisawa N, Chua GL, Zhang X, Wong YK, Su L, Wong MX, Yang J, Jens MT, Li Z, Sun H, Wang Y, Raul CD, Shah SJ, Gao C, Liu Y, “BCAA catabolism targeted therapy for heart failure with preserved ejection fraction.”, Theranostics, 2025, 6257-6273, Doi:10.7150/thno.105894 PMID:40521197
  5. Yu J, Wang W, Yang J, Zhang Y, Gong X, Luo H, Cao N, Xu Z, Tian M, Yang P, Mei Q, Chen Z, Li Z, Li C, Duan X, Rex Lyu Q, Gao C, Zhang B, Wang Y, Wu G, Zeng C, “Correction to: LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.”, Circulation research, 2025, e52, Doi:10.1161/res.0000000000000711 PMID:40146802
  6. Gao C, Song N, Wang Y, “A New GRK2 Inhibitor for Heart Failure.”, JACC. Basic to translational science, 2025, 218-220, Doi:10.1016/j.jacbts.2024.12.006 PMID:40131156
  7. Liang J, Wang X, Ortiz F, Shishodia G, Liu T, Gao C, Williams NS, Chuang DT, Wynn RM, Ready JM, “Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity.”, ACS medicinal chemistry letters, 2024, 1899-1906, Doi:10.1021/acsmedchemlett.4c00362 PMID:39563832
  8. Bi F, Gao C, Guo H, “Epigenetic regulation of cardiovascular diseases induced by behavioral and environmental risk factors: Mechanistic, diagnostic, and therapeutic insights.”, FASEB bioAdvances, 2024, 477-502, Doi:10.1096/fba.2024-00080 PMID:39512842
  9. Gao C, Zhu J, Song N, Wang Y, “Tumour necrosis factor receptor-associated factor 7: a new member of the E3 ligase family in cardiac hypertrophy.”, Cardiovascular research, 2024, 1987-1988, Doi:10.1093/cvr/cvae225 PMID:39436773
  10. Culler KL, Sinha A, Filipp M, Giro P, Allen NB, Taylor KD, Guo X, Thorp E, Freed BH, Greenland P, Post WS, Bertoni A, Herrington D, Gao C, Wang Y, Shah SJ, Patel RB, “Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction.”, Scientific reports, 2024, 20694, Doi:10.1038/s41598-024-71329-y PMID:39237673
  11. Gao C, Xiong Z, Liu Y, Wang M, Wang M, Liu T, Liu J, Ren S, Cao N, Yan H, Drucker DJ, Rau CD, Yokota T, Huang J, Wang Y, “Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.”, Circulation research, 2024, 614-628, Doi:10.1161/circresaha.124.324706 PMID:39011638
  12. Gao C, Wang Y, “A New linc(-RNA) Between NFAT/MEF2 and Cardiac Hypertrophy.”, Circulation research, 2024, 450-452, Doi:10.1161/circresaha.124.324794 PMID:39024397
  13. Liu J, Liu T, Ren SV, Zhu C, Bouso E, Mamlouk S, Rau CD, Wang Y, Gao C, “Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure.”, Frontiers in cardiovascular medicine, 2023, 1226586, Doi:10.3389/fcvm.2023.1226586 PMID:38188257
  14. Gao C, Wang Y, “The Emerging Role of Circular RNAs in Cardio-Oncology.”, JACC. Basic to translational science, 2023, 699-701, Doi:10.1016/j.jacbts.2023.04.004 PMID:37426523
  15. Zhao H, Wang P, Wang X, Du W, Yang HH, Liu Y, Cui SN, Huang W, Peng T, Chen J, Gao C, Wang Y, Sadayappan S, Ma C, Fan Y, Wang C, Fan GC, “Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway.”, Cardiovascular research, 2023, 1981-1996, Doi:10.1093/cvr/cvad105 PMID:37392461
  16. Nishi K, Yoshii A, Abell L, Zhou B, Frausto R, Ritterhoff J, McMillen TS, Sweet I, Wang Y, Gao C, Tian R, “Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes.”, Cell reports, 2023, 112641, Doi:10.1016/j.celrep.2023.112641 PMID:37310861
  17. Langenbacher AD, Lu F, Crisman L, Huang ZYS, Chapski DJ, Vondriska TM, Wang Y, Gao C, Chen JN, “Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology.”, Journal of cardiovascular development and disease, 2023, 221, Doi:10.3390/jcdd10050221 PMID:37233188
  18. Yu JY, Cao N, Rau CD, Lee RP, Yang J, Flach RJR, Petersen L, Zhu C, Pak YL, Miller RA, Liu Y, Wang Y, Li Z, Sun H, Gao C, “Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice.”, Acta pharmacologica Sinica, 2023, 1380-1390, Doi:10.1038/s41401-023-01076-9 PMID:36991098
  19. Ragni M, Greco CM, Felicetta A, Ren SV, Kunderfranco P, Ruocco C, Carullo P, Larcher V, Tedesco L, Severi I, Giordano A, Cinti S, Valerio A, Sun H, Wang Y, Gao C, Condorelli G, Nisoli E, “Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction.”, Cardiovascular research, 2023, 982-997, Doi:10.1093/cvr/cvad005 PMID:36626303
  20. Gao C, Gong J, Cao N, Wang Y, Steinberg SF, “Lipid-independent activation of a muscle-specific PKCα splicing variant.”, American journal of physiology. Heart and circulatory physiology, 2022, H825-H832, Doi:10.1152/ajpheart.00304.2022 PMID:36112502
  21. Gao C, Wang Y, “Cardio-Protective Messengers From "Good Fat".”, Circulation research, 2022, 1507-1509, Doi:10.1161/circresaha.122.321143 PMID:35549369
  22. Feng Y, Cai L, Hong W, Zhang C, Tan N, Wang M, Wang C, Liu F, Wang X, Ma J, Gao C, Kumar M, Mo Y, Geng Q, Luo C, Lin Y, Chen H, Wang SY, Watson MJ, Jegga AG, Pedersen RA, Fu JD, Wang ZV, Fan GC, Sadayappan S, Wang Y, Pauklin S, Huang F, Huang W, Jiang L, “Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy.”, Circulation, 2022, 1663-1683, Doi:10.1161/circulationaha.121.055781 PMID:35400201
  23. Dai Z, Cheng J, Liu B, Yi D, Feng A, Wang T, An L, Gao C, Wang Y, Zhu MM, Zhang X, Zhao YY, “Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis.”, Journal of the American Heart Association, 2021, e022077, Doi:10.1161/jaha.121.022077 PMID:34743552
  24. Gao C, Yu J, Wang Y, “Branched chain amino acids in cardiac growth and pathology - timing is everything.”, Journal of molecular and cellular cardiology, 2021, 14-15, Doi:10.1016/j.yjmcc.2021.05.020 PMID:34119505
  25. Gao C, Cao N, Wang Y, “Metal dependent protein phosphatase PPM family in cardiac health and diseases.”, Cellular signalling, 2021, 110061, Doi:10.1016/j.cellsig.2021.110061 PMID:34091011
  26. Gao C, Cao N, Wang Y, “The coming of age for branched-chain amino acids.”, The journal of cardiovascular aging, 2021, Doi:10.20517/jca.2021.02 PMID:34568877
  27. Qin JJ, Cheng X, Zhou F, Lei F, Akolkar G, Cai J, Zhang XJ, Blet A, Xie J, Zhang P, Liu YM, Huang Z, Zhao LP, Lin L, Xia M, Chen MM, Song X, Bai L, Chen Z, Zhang X, Xiang D, Chen J, Xu Q, Ma X, Touyz RM, Gao C, Wang H, Liu L, Mao W, Luo P, Yan Y, Ye P, Chen M, Chen G, Zhu L, She ZG, Huang X, Yuan Y, Zhang BH, Wang Y, Liu PP, Li H, “Redefining Cardiac Biomarkers in Predicting Mortality of Inpatients With COVID-19.”, Hypertension (Dallas, Tex. : 1979), 2020, 1104-1112, Doi:10.1161/hypertensionaha.120.15528 PMID:32673499
  28. Gao C, Wang Y, “mRNA Metabolism in Cardiac Development and Disease: Life After Transcription.”, Physiological reviews, 2020, 673-694, Doi:10.1152/physrev.00007.2019 PMID:31751167
  29. Chen M, Gao C, Yu J, Ren S, Wang M, Wynn RM, Chuang DT, Wang Y, Sun H, “Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure.”, Journal of the American Heart Association, 2019, e011625, Doi:10.1161/jaha.118.011625 PMID:31433721
  30. Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro RJ, Wang Y, Ford DA, Domeier TL, Padilla J, Rector RS, Emter CA, “Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.”, JACC. Basic to translational science, 2019, 404-421, Doi:10.1016/j.jacbts.2019.02.004 PMID:31312763
  31. Gao C, Ren SV, Yu J, Baal U, Thai D, Lu J, Zeng C, Yan H, Wang Y, “Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.”, JACC. Basic to translational science, 2019, 161-172, Doi:10.1016/j.jacbts.2018.11.001 PMID:31061918
  32. Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, Gou LT, Zhou Y, Zhang J, Ren S, Chen J, Wang Y, Fu XD, “RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure.”, Proceedings of the National Academy of Sciences of the United States of America, 2019, 6172-6180, Doi:10.1073/pnas.1822176116 PMID:30867288
  33. Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S, “PKC and PKN in heart disease.”, Journal of molecular and cellular cardiology, 2019, 212-226, Doi:10.1016/j.yjmcc.2019.01.029 PMID:30742812
  34. Lue Y, Gao C, Swerdloff R, Hoang J, Avetisyan R, Jia Y, Rao M, Ren S, Atienza V, Yu J, Zhang Y, Chen M, Song Y, Wang Y, Wang C, “Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.”, American journal of physiology. Heart and circulatory physiology, 2018, H634-H643, Doi:10.1152/ajpheart.00155.2018 PMID:29775411
  35. Gao C, Wang Y, “Untangle a Broken Heart via Janus Kinase 1.”, Circulation research, 2017, 589-590, Doi:10.1161/circresaha.117.311684 PMID:28860312
  36. Gao C, Howard-Quijano K, Rau C, Takamiya T, Song Y, Shivkumar K, Wang Y, Mahajan A, “Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction.”, PloS one, 2017, e0177750, Doi:10.1371/journal.pone.0177750 PMID:28542617
  37. Rau CD, Gao C, Wang Y, “Deconvolution of the Human Endothelial Transcriptome.”, Cell systems, 2016, 218-220, Doi:10.1016/j.cels.2016.09.006 PMID:27684186
  38. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y, “The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.”, Nature medicine, 2016, 1131-1139, Doi:10.1038/nm.4179 PMID:27618650
  39. Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y, “Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.”, Circulation, 2016, 2038-2049, Doi:10.1161/circulationaha.115.020226 PMID:27059949
  40. Gao C, Wang Y, “Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy.”, Hypertension (Dallas, Tex. : 1979), 2016, 841-842, Doi:10.1161/hypertensionaha.116.07140 PMID:27021013
  41. Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu XD, Chen JN, Wang Y, “RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.”, The Journal of clinical investigation, 2016, 195-206, Doi:10.1172/jci84015 PMID:26619120
  42. Pan BF, Gao C, Ren SX, Wang YB, Sun HP, Zhou MY, “Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells.”, Acta pharmacologica Sinica, 2015, 1480-1486, Doi:10.1038/aps.2015.119 PMID:26592513
  43. Sun H, Gao C, Wang Y, “A H(a)rd Way to Adapt in Cardiac Hypertrophy.”, Circulation research, 2015, 484-486, Doi:10.1161/circresaha.115.307164 PMID:26316602
  44. Gao C, Wang Y, “Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.”, Circulation journal : official journal of the Japanese Circulation Society, 2014, 1038-1047, Doi:10.1253/circj.cj-14-0412 PMID:24759793
  45. Foster WH, Langenbacher A, Gao C, Chen J, Wang Y, “Nuclear phosphatase PPM1G in cellular survival and neural development.”, Developmental dynamics : an official publication of the American Association of Anatomists, 2013, 1101-1109, Doi:10.1002/dvdy.23990 PMID:23723158
  46. Gao C, Wang Y, “Global impact of RNA splicing on transcriptome remodeling in the heart.”, Journal of Zhejiang University. Science. B, 2012, 603-608, Doi:10.1631/jzus.b1201006 PMID:22843179
  47. Zhou M, Lu G, Gao C, Wang Y, Sun H, “Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm).”, The Journal of biological chemistry, 2012, 23397-23406, Doi:10.1074/jbc.m112.351031 PMID:22589535
  48. Lee JH, Gao C, Peng G, Greer C, Ren S, Wang Y, Xiao X, “Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts.”, Circulation research, 2011, 1332-1341, Doi:10.1161/circresaha.111.249433 PMID:22034492
  49. Zhang M, Zhao C, Du L, Lu F, Gao C, “Expression, purification, and characterization of a thermophilic neutral protease from Bacillus stearothermophilus in Bacillus subtilis.”, Science in China. Series C, Life sciences, 2008, 52-59, Doi:10.1007/s11427-008-0009-9 PMID:18176791